Histamine Intolerance

Histamine Intolerance

Histamine intolerance is a condition that is gaining recognition in the medical community yet remains widely misunderstood. It can affect individuals of all ages and genders, but its impact on women during menopause is particularly noteworthy. To comprehend the complexities and implications, it is essential to delve into what histamine is, the concept of histamine intolerance, its manifestation in menopausal women, treatment options, and ongoing research in this field.

What is Histamine?

Histamine is a biogenic amine that acts as a neurotransmitter in the human body. It plays a crucial role in various physiological processes, including the regulation of immune responses, gastrointestinal function, and neurotransmission. Histamine is synthesized from the amino acid histidine by the enzyme histidine decarboxylase and is primarily stored in mast cells and basophils.

Unravelling the Mystery

The condition is characterized by an impaired ability to metabolize histamine efficiently. Unlike histamine allergies, which involve an immune response triggered by histamine, histamine intolerance occurs when there is an imbalance between histamine levels and the body’s capacity to break it down. This imbalance can lead to a wide range of symptoms, including but not limited to headaches, digestive issues, skin problems, and respiratory difficulties.


During menopause, women undergo significant hormonal changes, including a decline in oestrogen levels. Oestrogen plays a role in regulating the enzyme diamine oxidase (DAO), which is responsible for breaking down histamine in the body. Therefore, the decrease in oestrogen levels can potentially exacerbate intolerance symptoms in menopausal women. Common symptoms experienced during menopause, such as hot flashes, mood swings, and insomnia, may overlap with those of this condition, making diagnosis and management challenging.

Treatment Options 

Managing histamine intolerance often involves a multi-faceted approach tailored to individual needs. Dietary modifications are typically recommended, with a focus on reducing histamine-rich foods such as aged cheeses, fermented foods, and processed meats. Additionally, DAO supplementation may help improve histamine metabolism in some individuals. Antihistamines are commonly used to alleviate symptoms, although they do not address the underlying causes. 

Research Insights 

Research into histamine intolerance is still in its nascent stages, but recent studies have shed light on its mechanisms and potential therapeutic strategies. For instance, a study published in the Journal of Personalized Medicine titled “Histamine Intolerance: The Current State of the Art” provides a comprehensive overview of the current understanding of histamine intolerance and its clinical implications [1]. Another study, “The dietary treatment of histamine intolerance reduces the abundance of some histamine-secreting bacteria of the gut microbiota in histamine intolerant women,” explores the impact of dietary interventions on gut microbiota composition in histamine intolerant individuals [2]. However, despite these advancements, much remains to be elucidated, as highlighted in a paper titled “Histamine Intolerance—The More We Know the Less We Know” [3].


In conclusion, this condition is complex and can significantly impact the quality of life, particularly for women experiencing menopause. While research into histamine intolerance has advanced in recent years, there is still much to uncover regarding its etiology, diagnosis, and management. By deepening our understanding and its interplay with menopause, we can better tailor therapeutic approaches to alleviate symptoms and improve overall well-being.



  1. Maintz, L., & Novak, N. (2020). Histamine Intolerance: The Current State of the Art. Journal of Personalized Medicine, 10(3), 118. [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7463562
  2. Schnedl, W. J., Schenk, M., Lackner, S., Enko, D., Schenk, M., & Mangge, H. (2021). The dietary treatment of histamine intolerance reduces the abundance of some histamine-secreting bacteria of the gut microbiota in histamine intolerant women. Nutrients, 13(2), 438. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9633985/
  3. Maintz, L., & Schwarzer, V. (2021). Histamine Intolerance—The More We Know the Less We Know. Nutrients, 13(6), 1751. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8308327/